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Upregulation of the PD-L1/PD-1 axis induces T cell exhaustion, while the expression of dont eat me signals, such as CD47 (interacting with SIRP) and CD24 (interacting with Siglec-10), prevents macrophage-mediated phagocytosis

Yet, more recently, a metabolomic analysis reveals the importance of glutamine uptake by ASCT2 and its conversion into ROS-producing intermediate metabolite -Ketoglutarate as marker of sensitivity during sulfasalazine xCT-inhibition cell death in head and neck squamous cells carcinoma (46)