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As a result, recent international guidelines emphasize the pivotal role of GLP-1 receptor agonists, particularly for individuals with atherosclerotic cardiovascular disease or obesity
![inhibitory glp 1 Mechanisms of dipeptidyl peptidase4 (DPP4) inhibitors, glucagonlike glp-1_analogs [TUSOM | Pharmwiki]](https://tmedweb.tulane.edu/pharmwiki/lib/exe/fetch.php/glp1.png?w=600&tok=baf39c)
Its rich antioxidants and healthy fat content can help curb cravings, making it easier to manage weight while on GLP-1, says Margulies
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But tirzepatide dual receptor activation makes it significantly more potent milligram-for-milligram, and skipping the titration process risks severe gastrointestinal side effects even in people who tolerated high-dose semaglutide without issues
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