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Remaining in Glasgow until 1958, Black used this period to continue researching the gut which he did in collaboration with Adam Smith, a gastro-intestinal surgeon who was exploring agents that stimulated gastric secretions
The most commonly reported adverse effects in Phase 2 trials were gastrointestinal in nature, including: Nausea (the most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent and most pronounced during dose escalation, typically improving over time
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