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Patients report shorter downtimes and quicker return to work and play
Moreover, existing studies mostly focus on the regulation of RA synovial cells (such as FLS) or macrophages by the cGAS-STING pathway, whereas this study, for the first time, clearly demonstrates the central role of the cGAS-STING-ferroptosis axis in RA chondrocytes, and reveals that GLP-1RAs exerted therapeutic effects on RA through a dual mechanism of directly inhibiting this axis and simultaneously promoting the M2 polarization of macrophages
Of those surveyed, 5% had personally taken a GLP-1 medication, while 9% knew friends or family members who had used one [19]
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