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further demonstrated that TMAO inhibits TGF- RI ubiquitination, reducing proteasomal degradation, prolonging its half-life, and sustaining Smad2 phosphorylation/fibrotic gene transcription (e.g., -SMA, collagen I) (Yang et al., 2019)
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These meta-analyses were more comprehensive, incorporating a larger number of studies, featuring more recent publications, and demonstrating greater statistical power compared to previous meta-analyses
Dec 2011;22(12):2313-2321
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