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Gulyaeva NV (2021) Stress-Associated Molecular and Cellular Hippocampal Mechanisms Common for Epilepsy and Comorbid Depressive Disorders
This metabolic switching is regulated by sirtuins, namely SIRT3 and SIRT2 repress the Warburg effect 342,343,344,345 , while SIRT5 maintains glycolysis 346
Over time, this leads to: Chronically elevated blood glucose Increased fat storage (especially abdominal fat) Persistent hunger and cravings Energy crashes Naturopathic interventions focus on stabilizing blood glucose through whole-food nutrition rich in fiber, protein, and healthy fats
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