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Previous research attributed sorafenibs therapeutic effect primarily to its multikinase inhibitory function, which halts cell proliferation, angiogenesis, and promotes tumor cell apoptosis (69, 70)

Rates are approximate from pivotal trials and may differ across studies

Critically, initiating this therapy pathway raises the very real prospect of a lifelong commitment to medication, a significant financial burden for many families, and questions about equity of access

Furthermore, amino acid metabolic reprogramming is closely associated with malignant characteristics of HCC, including metastasis, apoptosis, and chemoresistance