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Thus, high GE (HGE) and high GI (HGI) neurons increase or decrease their frequency of potential actions, respectively, in response to increases in interstitial glucose from 5 to 20 mM, although these neurons are still not thoroughly characterized, and there are doubts about their physiological significance
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Cardiovascular and other outcomes Semaglutide is approved by the FDA for reducing the risk of major adverse cardiovascular events (MACE) in adults with type 2 diabetes and those with diagnosed heart disease
Tirzepatide has shown similar results: in a phase 2 trial, up to 73.3% of participants at the highest dose achieved MASH resolution without worsening fibrosis at 52 weeks, compared to 13.2% on placebo
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