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When starting GLP-1 therapy in patients already taking insulin or sulphonylureas, doses of these medications may need to be reduced to prevent hypoglycaemia

Functional experiments confirmed that, compared with exosomes from healthy pregnant women, exosomes from GDM patients increased the expression of genes related to glycolysis and gluconeogenesis in placental cells, suggesting that adipose tissue-derived exosomes contribute to GDM pathology by regulating placental metabolism

Side effects cluster in the first 72 hours after each weekly injection and in the first 2 to 4 weeks of every dose escalation

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