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Additionally, large aggregates can trigger immune responses in animal models or interfere with assay systems in cell-based research

In 2025, the most common plan types were: PPOs (46%), HDHP/SOs (33%), Health Maintenance Organizations (HMOs) (12%), Point-of-service plans (POS) plans (9%), and conventional indemnity plans (less than 1%)

Manual stimulation of the tails was performed next using the standardized stretch/rub maneuver followed by scoring according to the Bennett scale

Excess adipose tissue can: Compress lymphatic vessels Increase inflammation Reduce lymphatic pumping efficiency Increase lymphatic fluid production Impair immune function Over time, these changes can overwhelm the lymphatic system and contribute to chronic swelling