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Semaglutide and tirzepatide are "upstream" they act on incretin receptors to influence appetite regulation, gastric emptying, and glucose-dependent insulin secretion
It has a stronger and longer-lasting action in the body, enabling a higher dosage to result in more weight reduction
In one study, participants regained two-thirds of their previous weight loss within the year after stopping the medication
A study in JAMAs Ophthalmology Journal found that those who have used GLP-1 drugs are at a higher risk of developing NAION than those who were prescribed alternative diabetes control medications
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