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The heart benefit and the weight loss benefit appear to operate on different timescales and through different mechanisms

Do the six RCTs in the meta-regression give any signal on which patient phenotype holds onto that residual loss, or is the data too heterogeneous to split out yet

For families, even modest reductions in heavy drinking can mean greater stability, fewer crises and improved quality of life. These findings suggest oral semaglutide may: Help people reduce harmful drinking even without full abstinence Offer a new treatment option for individuals who do not respond to existing medications Reduce alcohol-related health, safety and social harms Safety and next steps Oral semaglutide was generally well tolerated, with most side effects reported as mild