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Body composition studies from the STEP clinical trials have shown that while fat mass loss is the primary outcome, some lean mass reduction does occur during GLP-1 receptor agonist therapy
Some women experience brief nausea, especially during the first few doses
Famularo G, Moretti S, Marcellini S, et al
Together, these pathways explain why semaglutides cholesterol benefits are consistent, even if modest compared to statins
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