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Metabolomic and fluxomic studies showed that increased CysSSH production by upregulated CSE promotes resistance against BRAF(V600E)-targeted therapy, through protection against drug-induced oxidative damage and feeding the increased cellular energy demand of persister cells
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The study, conducted on almost 2,000 people, showed an average 15kg weight loss during the 15-month trial
Injections may be discussed for more body-wide effects, but the route should be clinician-led
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