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Case series, such as Richards et al., also reported decreased AUD symptoms based on alcohol use disorder identification test score in patients receiving Semaglutide for weight loss, further corroborating the potential of GLP-1RAs across formulations [40]
Whilst the dynamic range of this assay was low in our hands, making it challenging to apply to higher throughput screening efforts or to concentration responses, it could be adapted by the use of alternative fluorophores with greater signal separation from the nanoluciferase emission peak (Dale et al ., 2019) or using complementation approaches (Inoue et al ., 2019)
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Now in phase 3, having been greenlit to begin trials by the FDA, Viking finished enrolling all its patients in November
