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Researchers at University of California San Diego School of Medicine have reported results from a large international clinical trial showing that semaglutide, a medication in the GLP-1 class of drugs widely used to treat diabetes and obesity, may help reduce liver scarring in patients with advanced fatty liver disease, including those with early-stage cirrhosis

In animal studies SGLT2 inhibitors were excreted in breast milk and affected neonatal growth, but human data are not available

Its gastroprotective and gut-healing properties could allow patients to tolerate higher GLP-1 agonist doses (and thus achieve greater weight loss) by buffering the nausea and GI distress that otherwise limit dose escalation

Lanfer A, Knof K, Barba G, Veidebaum T, Papoutsou S, de Henauw S, et al