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For rigorous synergy evaluation, researchers should use full concentration-response curves for each peptide alone and a two-dimensional concentration matrix of the combination, pre-define the additivity model (e.g., Bliss independence or Loewe additivity), state the calculation method, and perform independent biological replicates
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doi: 10.1007/s12028-015-0119-8 55 FujimuraS.ShimakageH.TaniokaH.YoshidaM.Suzuki-KusabaM.HisaH.et al
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