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Also check out episode 285, which features fentanyl
This is especially risky if you're also taking other diabetes medications
Both agents target glucose homeostasis through different mechanismsberberine activates AMPK and improves insulin sensitivity, while GLP-1 agonists enhance insulin secretion and slow gastric emptying, creating potential synergy rather than direct antagonism
Neuropsychopharmacology 43, 20002008
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