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The investigators hypothesized that this difference might be due to strain specificity (Ring et al., 2019), and Lius findings substantiated their hypothesis (Liu Q et al., 2021)

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Together, these data suggested that activating GLP-1R alleviated glycolysis, at least partially by the suppression of PFKFB3-driven glycolysis, and attenuated lactate-mediated histone lactylation, which in turn suppressed the transcription of profibrotic genes in TGF-1 + IL-1-challenged fibroblasts

While we focus mainly on analyzing inspection-based warning letters, we also offer general context on all warning letters for these product categories