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The combined GLP-1/GIP signal in tirzepatide is the mechanistic basis for its ~22.5% SURMOUNT-1 result, outperforming semaglutide's STEP 1 figure by roughly 7.6 percentage points
Pharmaceutical firm Novo Nordisk introduced semaglutide in 2012, modifying the GLP-1 sequence to enhance its stability and half-life
Access to diabetes prevention programs varies across provinces
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