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Healthcare providers must monitor patients closely, as safety guidelines require proper dosing and consideration of common side effects, particularly gastrointestinal symptoms
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Taken together with the findings that utilization of esketamine as an antidepressant increases LAC levels [59], the fact that the decrease in LAC levels in subjects with MDD is independent of psychotropic drug treatment raises the possibility that increasing LAC levels may be needed to induce antidepressant effects
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