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First, the dose range of 2.5 to 10 mg per injection reflects the range used in clinical practice and early-phase research
Its main mechanism of action is based on increasing the expression of BDNF (Brain-Derived Neurotrophic Factor) and its TrkB receptors in the hippocampus and prefrontal cortex, promoting synaptic plasticity, long-term potentiation (LTP), and memory consolidation (Dolotov et al., Neuroscience 2006)
29-gauge or 31-gauge insulin syringes produce less pain than thicker needles
Topical creams only do so much because they can't reach the deeper layers where collagen is produced
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