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reintroduce a varied diet as symptoms improve For constipation: Gradually increase dietary fibre through vegetables, fruit, and wholegrains Ensure adequate fluid intake throughout the day Light physical activity, such as walking after meals, can stimulate bowel motility For diarrhoea: Temporarily reduce high-fibre or high-fat foods Avoid artificial sweeteners (sorbitol, xylitol), which have a laxative effect [23] Rehydrate carefully with water or, if needed, oral rehydration salts (ORS) solutions (available from pharmacies), which are more appropriate than general sports or electrolyte drinks for replacing fluid and electrolytes lost through diarrhoea For people with diabetes: If you are taking insulin or a sulfonylurea alongside retatrutide, reduced appetite and food intake may increase your risk of hypoglycaemia (low blood glucose)

How long until weight or glucose effects appear

GLP-1 RAs exert immunomodulatory properties through peripheral and central pathways