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Monitoring and adjustments: Regular blood tests to check B12 levels Assessing if symptoms get better or worse Changing the injection frequency as needed By customizing the B12 injection schedule, healthcare providers can make treatment more effective

During cisplatin-induced acute kidney injury (AKI), ferroptosis in renal cells is due to the downregulation of DHODH, a key enzyme in mitochondrial pyrimidine synthesis, and its downstream product CoQH2, which exacerbates cisplatin-induced CoQH2 deficiency and LPO, while also causing mitochondrial dysfunction and SIRT3 SUMOylation

Treatment is always tailored to individual needs and carried out under medical supervision to ensure safety and effectiveness