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Triggered by upstream signals, the initiator caspases undergo autocleavage, and the subsequently activated cleaved initiator caspases stimulate the downstream executioner caspases to execute apoptosis (106)

It has improved stability compared to native GHRH, allowing more sustained signaling in experimental settings

At lower doses, the increases were proportionally smaller, generally ranging from 2 to 5 beats per minute depending on the specific dose and titration schedule

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