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If a GLP-1 medication is stopped, those conditions should be reassessed, since weight regain can increase medication requirements, he says
The absence of glucagon receptor activation means Semaglutide relies more heavily on appetite suppression, which may increase the proportion of lean mass lost
consider Metformin dose reduction if A1C below 6.5% Week 24+: If A1C stable below 6.0%, consider further Metformin reduction with close monitoring The additive effects of combination therapy were suggested by the trial subgroup analyses
In short, they curb the users appetites so they eat less
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