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In vitro studies of human breast cancer cell lines, including ER positive (MCF-7 and T47D), HER2+ (SK-BR-3) and triple negative (MDA-MB-231 and BT-549) models, have been very helpful in understanding the molecular mechanisms that regulate natural supplements as they modify growth progression, apoptosis, cell cycle control, invasion ability and metastatic capacity (220)

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This susceptibility is compounded by impaired redox homeostasis and multiple pathogenic factors: i) dysfunctional protein clearance mechanisms involving PTEN-induced kinase 1 (PINK1), Parkin, and -synuclein proteostasis

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