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First-line obesity treatments include lifestyle intervention (e.g., low-calorie diets) and behavioral modification therapies 4,5 since approved obesity medications have limited efficacy and commonly have side effects 6
This pattern developed from several considerations
Therefore, IGF-1 deprivation seriously contributes to the progressive malnutrition of cirrhotic patients, increasing the vulnerability of the liver to an inflammatory and oxidative microenvironment with mitochondrial dysfunction
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