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The mechanism is unclear but may relate to rapid B12 mobilization in deficient patients
Animal physiology differs significantly from humans, limiting direct translation
Figure 2 presents the observed overall mean semaglutide concentrations and variability (90% concentration ranges for within and between individuals) during and following 10 days of oral dosing at various dosing conditions
ICH Q3A(R2) describes general impurity categories for chemically synthesized substances, and ICH Q3C(R9) describes the control of residual solvents
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