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Intestinal signals are relayed through the gut-brain axis via vagal and hypothalamic pathways, coordinating appetite, energy expenditure, and fat storage
Therefore, GLP-1RAs that mimic the function of native GLP-1 but with improved pharmacokinetics are highly desirable as drug candidates for the management of T2DM (Wang et al., 2022)
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Palmitoylethanolamide (PEA) is an 18-carbon long- chain fatty acid
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