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Nausea, diarrhoea, vomiting, and constipation occur frequently, particularly during the initial treatment period
Our results provide a possible mechanism in which upregulation of phosphorylated p53 and p16 maintain the cell cycle arrest of keloid fibroblasts, and FOXO4-DRI selectively induces apoptosis of keloid senescent fibroblasts by prompting p53-pS15 nuclear exclusion
no human RCTs have established efficacy
