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POLG mutation in a patient with cataracts, early-onset distal muscle weakness and atrophy, ovarian dysgenesis and 3-methylglutaconic aciduria
Yes, its plugged into a wall and you are dragging a long wire
doi: 10.1056/NEJMoa1811744 12 MarsoSPDanielsGHBrown-FrandsenKKristensenPMannJFNauckMAet al
The defection of mitophagy will lead to the accumulation of dysfunctional mitochondria, resulting in the leakage of Cytc into the cytoplasm to induce the activation of the caspase signaling pathway, and contribute to cell death (Sinha et al., 2013
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