GHK-Cu operates through copper-mediated signaling without the retinoid irritation profile
Exp Clin Gastroenterol 1:1516, 1991 Sikiric P, Petek M, Rucman R, Grabarevic Z, Seiwerth S, Rotkvic I, Jagic V, Danilovic Z, Dodig M, Duvnjak M, Artukovic B, Dzaja P, Senecic I, Suchanek E, Giljanovic S, Mise S, Djarmanovic Z: Beneficial effect of a new gastric juice peptide, body protection compound, in acute pancreatitis models
The safety margin is over 300 times the therapeutic dose, making GHK-Cu one of the safest peptides available for research use
So, unless youre deficient, megadoses of vitamin B12 may be just passing through your body and making some organs work harder (NIH-a, 2021)