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Leptin is a hormone involved in regulating energy balance and appetite, which could imply that increased food intake may contribute to the observed weight gain in peptide-exposed models, which then may increase leptin levels and subdue appetite
(Table 3) These results indicate that while both treatment modalities led to significant reductions in weight and BMI over time, the addition of semaglutide to IGB therapy yielded significantly superior outcomes, especially evident at 6 and 12 months of follow-up
GLP or Glucagon Like peptide is a hormone produced by the intestines in response to food intake and helps in Controlling appetite Controlling blood sugar Control intestinal movement As both medications are GLP-1 analogues, they have similar side effects and safety profile
doi: 10.1111/head.12838 21
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