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In theory, combining agents that both reduce adiposity and improve insulin sensitivity could produce additive or synergistic metabolic effects but this is entirely speculative and unproven in humans

It isnt clear how the synergy arises, but additional research using the peptide may reveal novel pathways for improving cartilage growth, a notoriously challenging clinical problem

LEfSe is known to reduce false positives and can highlight biological consistency across subclasses, while the KruskalWallis test used alone can achieve a lower false-negative rate compared to LEfSe 38

The two terms are used interchangeably in clinical and research literature