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Early phase response (weeks 1-2) Initial responses to combination therapy typically manifest as reduced inflammation and pain at injury sites

Metformin slows glucose absorption in the intestines Metformin also helps by inhibiting sodium-glucose cotransporter 1 (SGLT1) , and this process helps reduce glucose absorption in the small intestine

It is known that some polymorphism of MTHFR would result in reduction of MTHFR enzyme activity as well as DNA methylation process, later shown to have significant impacts in various psychiatric diseases

Observations are made under standardized conditions to ensure consistency and repeatability