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The original mouse study used roughly 3 weeks of alternating-day treatment
Zhu Y, Xu F, Chen H, Zheng Q
If you're on a 1ml weekly protocol and seeing no measurable change after six weeks, the problem is almost never 'too low a dose.' It's either formulation quality (underdosed methionine or choline), dietary interference (you're in maintenance calories, not deficit), or liver saturation (you're already consuming high dietary methionine and adding more doesn't shift the pathway further)
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