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This variability likely reflects heterogeneity in the biological drivers of obesity across individuals, suggesting opportunity for precision medicine approaches that match patients to optimal therapeutic mechanisms

Whether the spectacular preclinical pharmacology of GLP-1R/GcgR co-agonists will translate through successful phase 3 registration trials is a question that will be answered in the coming years, but the pursuit of multifunctional, targeted therapeutics is destined to continue

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Innovation : The current AOM pipeline comprises 157 clinical-stage assets, including 7 in phase 3, and spans over 60 mechanisms of action, while 43% of all AOM assets are oral therapies (see Figure 2)