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As with any new combination, it is worth introducing them gradually and checking in with a healthcare provider about what fits your needs
Topiramate can increase the level of acid in your blood (metabolic acidosis)
The compound is not listed on any controlled substance schedule in the US, meaning possession without intent to distribute exists in a legal gray area rather than being explicitly prohibited
The R group side chains may be nonpolar, polar uncharged, or charged, depending on the functional group, pH, and the pKa of any ionizable side-chain group
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