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Increases in ACE1, or a decrease in ACE2 caused by SARS-CoV-2 in infected cells, may reflect an increased inflammatory state characteristic of severe COVID-19 (ref
Elevated [Ca 2+ ] i in rat GCs may be a result of exendin-4-induced PKA activation, because our experiments demonstrated that exendin-4 no longer caused changes in [Ca 2+ ] i when PKA activity was blocked by H-89 (Fig
However, the outcomes remain controversial
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