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Careful Administration (Use with Caution) 14

These stimuli drive the accumulation of pro-apoptotic B-cell lymphoma 2 (Bcl-2) proteins on the outer mitochondrial membrane (OMM), thereby enhancing OMM permeabilization (102, 103)

So our hypothesis is around neuroinflammation, but defined in a way where you could say it's both peripheral inflammation and the effect it has on the vasculature, it's the effect on the blood-brain barrier