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However, with the prevalence of skin permeation enhancement methods (such as microneedles and laser) used in cosmetic and pharmaceutical industry 15 , copper compounds may pose a higher risk to cause skin irritation, which necessitates a thorough skin toxicity testing

They are firing in response to stimuli that normally would not trigger a strong signal

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This can create a thinner or more aged appearance, sometimes referred to as Ozempic face. This is not harmful, but it is something we can address conservatively if it becomes a concern