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38 In the CheckMate 915 study, synergistic integration of dynamic ctDNA monitoring with static analysis of tumor immune microenvironment biomarkers enabled early and accurate prediction of resistance risk to adjuvant immunotherapy in melanoma
Its mechanism is competitive inhibition within the NNMT catalytic pocket, blocking the methyl transfer from SAM to nicotinamide
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24 This opens the door to exploring these novel compounds as potential therapeutic agents in a broader range of conditions
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