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Central Weight Gain Not Responding to Lifestyle Changes When a patient has implemented consistent, evidence-based lifestyle changesadequate protein intake, resistance training, blood sugarsupportive nutritionand continues to gain visceral fat, GLP-1 therapy may be considered

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Holst, who discovered and described GLP-1, explains its role as a gut-derived hormone that regulates appetite, insulin secretion, and digestion, offering a groundbreaking approach to managing obesity and type 2 diabetes

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