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Clinicians should note that these medications do not replace established therapies such as reninangiotensin system inhibitors or SGLT2 inhibitors
Figure 1 Paracetamol for the Early Management of COVID-19: A Critical Viewpoint As discussed above, a precautionary principle regarding the risk of bacterial superinfections and of ACE2 overexpression was the main reason for the decision to discourage the use of NSAIDs (Micallef et al., 2020a
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One systematic review reported that use of exenatide 20 mcg twice daily resulted in an additional 1.4 kg weight loss, whilst exenatide 2 mg once weekly was associated with 1.6 kg additional weight loss compared with placebo [30]
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