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in Clinical Pharmacology & Therapeutics found subcutaneous injection reached peak plasma concentration (Tmax) at 75 minutes versus 38 minutes for IM, but area-under-curve (total bioavailability) was statistically equivalent at 94% versus 97%
Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinsons disease by regulating gut microbiota
251 Non-responders from both groups were then offered open-label BCG and both groups experienced an 18% response rate at seven months
This maintains effectiveness and prevents diminishing returns over time
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