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Introduction This is a common question for patients on compounded semaglutide or tirzepatide who notice skin changes during significant weight loss

Read counts were normalized by the trimmed mean of M -values method and differential expression was calculated using R package edgeR (v.3.28.1) and genewise negative binomial generalized linear models with quasi-likelihood tests method was used for statistical tests

These include injection site pain, headache, dizziness, and rarely, hypersensitivity reactions

Sleep tracking devices can provide objective data on sleep architecture changes, though these consumer devices vary in accuracy