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Consistent with the observations in human elderly Leydig cells, H2O2-induced senescent TM3 Leydig cells exhibited a predominant nuclear localization of FOXO4, in contrast to untreated controls where it remained mostly cytoplasmic
Patients should seek urgent medical attention if they develop severe, persistent abdominal pain
Senescence-associated -galactosidase (SA--gal) activity was measured in both cells and frozen tissues using a commercial kit, providing a visual and quantitative indicator of senescent cells
By scavenging free radicals, glutathione protects the mitochondria of the cell
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