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In pregnant rats administered tirzepatide during organogenesis, fetal growth reductions and fetal abnormalities occurred at clinical exposure in maternal rats based on AUC
STEP-2 (N=1,210 adults with type 2 diabetes) confirmed that even the 1.0 mg dose of semaglutide produces clinically significant metabolic changes within 8-12 weeks, which is well within the timeframe that ovulatory function may normalize in previously anovulatory women
The benefits usually outweigh the temporary discomfort
Rather than pulling them off the market, Caplan advocates for carefully monitoring these drugs, which can be a godsend for some obese people facing serious health concerns
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