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[24] This becomes especially valuable during caloric deficits, where every gram of protein counts

204 The accumulation of the hyperphosphorylated tau protein, a type of microtubule-associated protein (MAP), induces the formation of neurofibrillary tangles, and the aggregation of the amyloid-beta 1-42 (A42) fragment produced from APP results in the formation of senile plaques by disturbing the activity of PS1 and PS2

With respect to VPA, this agent depletes carnitine stores, especially during long-term or high-dose therapy, through various synergistic mechanisms [22, 3841]